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Influence of the Preparation Method on the Physicochemical Properties of Binary Systems of Econazole with Cyclodextrins by P Mura; M.T Faucci; A Manderioli; G Bramanti is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Influence of the Preparation Method on the Physicochemical Properties of Binary Systems of Econazole with Cyclodextrins about?

Equimolar combinations of econazole, a very poorly water soluble antifungal agent, with b-cyclodextrin and statistically substituted methyl-b-cyclodextrin were investigated for both solid state characterization (differential scanning calorimetry, hot-stage microscopy, infrared spectroscopy, scanning electron microscopy) and dissolution properties (dispersed amount method). The influence of the preparation method (physical mixing, ball-milling, kneading, sealed-heating) on the physicochemical properties of the products was evaluated. Kneading and sealedheating techniques led to amorphous products in the case of systems with methyl-b-cyclodextrin, whereas crystalline drug was still clearly detectable in all products with b-cyclodextrin. Independently of the preparation technique, all combinations with methyl-b-cyclodextrin yielded better performance than the corresponding ones with b-cyclodextrin. However, the influence of the preparation method was clearly more marked for products with methyl-b-cyclodextrin and made to be possible to better display the different performance of the examined carriers. In fact, the sealed-heated with the b-derivative showed an increase of drug dissolut

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Author

P Mura; M.T Faucci; A Manderioli; G Bramanti

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

1999

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)