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Time-course study of the Golgi-lysosome region of rat hepatocytes during early acute phase response to inflammation by Gro Thorne-Tjomsland; James C. Jamieson is a Medicine article available to read on EtoBox.

What is Time-course study of the Golgi-lysosome region of rat hepatocytes during early acute phase response to inflammation about?

Background: In a previous study of the hepatocyte Golgi apparatus 24 hr following the induction of the acute phase response to inflammation, it was found that the predominant secretory content was a granulofilamentous material (GFM), rather than lipoprotein particles (LP) as in controls (Thorne-Tjomsland and Jamieson, 1995, Anat. Rec., 241:439-450). The present study aimed to determine when and how this switch occurs and to monitor the Golgi-lysosome region of hepatocytes in general during early inflammation. Methods: Rats were injected with turpentine oil as an inflammatory agent. At 1,2,6,12, and 16 hr after turpentine-injection (TI), the livers were prefixed by perfusion with cacodylate-buffered glutaraldehyde, postfixed with ferrocyanide reduced osmium, and processed for thin section transmission electron microscopy. Results: LP were processed at all time points between 1 and 16 hr post-TI, and at 1 and 2 hr post-TI, the Golgi stacks were engorged with LP and therefore apparently processed more of these particles than in controls. A GFM was processed at later time points, starting at 12 h r post-TI. At the two time points when LP and GFM were co-processed, these materials were

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Author

Gro Thorne-Tjomsland; James C. Jamieson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0003-276X)

Published

1995

Language

EN

Field

Medicine (Health Sciences)