Can I read Reduction of drug‐induced yawning and penile erection and of noncontact erections in male rats by the activation of GABA~A~ receptors in the paraventricular nucleus: involvement of nitric oxide on EtoBox?

Reduction of drug‐induced yawning and penile erection and of noncontact erections in male rats by the activation of GABA~A~ receptors in the paraventricular nucleus: involvement of nitric oxide by Maria Rosaria Melis; Antonio Argiolas is a Neuroscience article available to read on EtoBox.

What is Reduction of drug‐induced yawning and penile erection and of noncontact erections in male rats by the activation of GABA~A~ receptors in the paraventricular nucleus: involvement of nitric oxide about?

## Abstract The effect of muscimol, a GABA~A~ receptor agonist, injected into the paraventricular nucleus (PVN) of the hypothalamus on drug‐induced (apomorphine, oxytocin and NMDA) yawning and penile erection, and on the increase in the concentration of NO~2~^–^ and NO~3~^–^ occurring in the paraventricular dialysate in these experimental conditions, was studied in male rats. Muscimol (50, 100 and 200 ng) reduced, in a dose‐dependent manner, penile erection and yawning induced by apomorphine (50 ng), oxytocin (30 ng) and NMDA (50 ng) delivered into the PVN. The reduction of penile erection and yawning was parallel to a reduction of the concomitant NO~2~^–^ and NO~3~^–^ increase that occurs in the paraventricular dialysate in this experimental condition. In contrast, baclofen (200 ng), a GABA~B~ receptor agonist, was ineffective. The muscimol effects on drug‐induced penile erection, yawning and NO~2~^–^ increase were prevented by the prior administration of bicuculline (250 ng into the paraventricular nucleus). Muscimol (200 ng) but not baclofen (200 ng), injected into the PVN, reduced both noncontact erections in male rats placed in the presence of an inaccessible receptive female,

Who reads Reduction of drug‐induced yawning and penile erection and of noncontact erections in male rats by the activation of GABA~A~ receptors in the paraventricular nucleus: involvement of nitric oxide?

Author

Maria Rosaria Melis; Antonio Argiolas

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)