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Organophosphate insecticides and acaricides antagonise bifenazate toxicity through esterase inhibition in Tetranychus urticae by Thomas Van Leeuwen; Steven Van Pottelberge; Ralf Nauen; Luc Tirry is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Organophosphate insecticides and acaricides antagonise bifenazate toxicity through esterase inhibition in Tetranychus urticae about?

## Abstract **BACKGROUND:** Bifenazate is a carbazate acaricide known for its potency, particularly against tetranychid mite species such as the two‐spotted spider mite, __Tetranychus urticae__ Koch (Acari: Tetranychidae). It was recently shown that the compound needs to be activated by an __S__,__S__,__S__‐tributyl‐phosphorotrithioate (DEF)‐sensitive mechanism in spider mites to display full acaricidal efficacy. The ability of well‐known organophosphates and carbamates to inhibit the activation of bifenazate and thus compromise its acaricidal potential was tested. **RESULTS:** Esterase activity determined __in vivo__ after pre‐exposure of mites with organophosphates and carbamates revealed–depending on the compound–varying esterase inhibition nicely correlated with the ability of the individual compound to antagonise bifenazate action on mites. **CONCLUSIONS:** The findings illustrate that organophosphates and carbamates interfere with bifenazate efficacy, most probably by inhibiting carboxylesterases responsible for the activation of the pro‐drug. As a result of the strong antagonism, mixtures of bifenazate with carbamates or organophosphates should not be used under field condit

Who reads Organophosphate insecticides and acaricides antagonise bifenazate toxicity through esterase inhibition in Tetranychus urticae?

Author

Thomas Van Leeuwen; Steven Van Pottelberge; Ralf Nauen; Luc Tirry

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-498X)

Published

2007

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)