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Can I read Interactions of Stiripentol with Clobazam and Valproate in the Mouse Maximal Electroshock-induced Seizure Model on EtoBox?
Interactions of Stiripentol with Clobazam and Valproate in the Mouse Maximal Electroshock-induced Seizure Model by Jarogniew J. Luszczki; Michal K. Trojnar; Neville Ratnaraj; Philip N. Patsalos; Stanislaw J. Czuczwar is a Medicine article available to read on EtoBox.
What is Interactions of Stiripentol with Clobazam and Valproate in the Mouse Maximal Electroshock-induced Seizure Model about?
The aim of this study was to characterize the anticonvulsant effects of stiripentol (STP) in combination with clobazam [CLB], and valproate [VPA]) in the mouse maximal electroshock (MES)-induced seizure model using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs). Potential adverse-effect profiles of interactions of STP with CLB and VPA at the fixed-ratio of 1:1 in the MES test with respect to motor performance, long-term memory and skeletal muscular strength were measured along with total brain antiepileptic drug concentrations. In the mouse MES model, STP administered singly had its DRRC non-parallel to that for CLB and, simultaneously, parallel to that for VPA. With type I isobolography for parallel DRRCs, the combinations of STP with VPA at three fixed-ratios of 1:3, 1:1 and 3:1 exerted sub-additive (antagonistic) interaction. Isobolography for non-parallel DRRCs revealed that the combination of STP with CLB at the fixed-ratio of 1:1 produced additive interaction. For all combinations, neither motor coordination, long-term memory nor muscular strength was affected. Total brain antiepileptic drug concentrations revealed b
Who reads Interactions of Stiripentol with Clobazam and Valproate in the Mouse Maximal Electroshock-induced Seizure Model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jarogniew J. Luszczki; Michal K. Trojnar; Neville Ratnaraj; Philip N. Patsalos; Stanislaw J. Czuczwar
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)