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Transferrin microheterogeneity in rheumatoid arthritis: Relation with disease activity and anemia of chronic disease by R. A. Feelders; G. Vreugdenhil; G. de Jong; A. J. G. Swaak; H. G. Van Eijk is a Medicine article available to read on EtoBox.

What is Transferrin microheterogeneity in rheumatoid arthritis: Relation with disease activity and anemia of chronic disease about?

We studied the relation between disease activity in rheumatoid arthritis (RA) and the microheterogeneity of transferrin. Using crossed immuno isoelectric focusing, transferrin microheterogeneity patterns were analyzed in sera of healthy individuals, nonanemic RA patients, iron deficient RA patients and RA patients with the anemia of chronic disease (ACD). In all RA groups a significant shift in the microheterogeneity pattern was observed, reflecting increased synthesis of transferrins with highly branched glycan chains. Increased disease activity correlated with both the induction of ACD and the change in transferrin glycosylation, which was, therefore, most pronounced in ACD. Generally, an increased synthesis of glycoproteins is accompanied by alterations in their glycosylation pattern. Since transferrin is a negative acute phase protein, our results indicated that changes in synthetic rates and changes in glycosylation induced in the acute phase response are regulated independently.

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Author

R. A. Feelders; G. Vreugdenhil; G. de Jong; A. J. G. Swaak; H. G. Van Eijk

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0172-8172)

Published

1992

Language

EN

Field

Medicine (Health Sciences)