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What is Enhancing CDDP Sensitivity via Ap Inhibition about?

1) The study examines how the DNA polymerase inhibitor aphidicolin (Ap) modulates drug resistance mediated by loss of mismatch repair (MMR) proteins in ovarian carcinoma cell lines. 2) Ap increases the sensitivity of MMR-deficient cell lines to cisplatin (CDDP) and N-methyl-N-nitrosourea (MNU) to a greater extent than MMR-proficient cell lines. 3) This supports the idea that Ap sensitizes drug-resistant cancer cells that have lost MMR by inhibiting replicative bypass, preferentially in MMR-deficient cells

Author

foskan

Language

EN