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Can I read Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice on EtoBox?
Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice by Robin van Eenige; Zhixiong Ying; Naomi Tramper; Vera Wiebing; Zohor Siraj; Jan Freark de Boer; Joost M. Lambooij; Bruno Guigas; Hongchang Qu; Tamer Coskun; Mariëtte R. Boon; Patrick C.N. Rensen; Sander Kooijman is a Medicine article available to read on EtoBox.
What is Combined glucose-dependent insulinotropic polypeptide receptor and glucagon-like peptide-1 receptor agonism attenuates atherosclerosis severity in APOE*3-Leiden.CETP mice about?
Background and aims Combined agonism of the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP1R) is superior to single GLP1R agonism in terms of glycemic control and lowering body weight in individuals with obesity and with or without type 2 diabetes mellitus. As both GIPR and GLP1R signaling have also been implicated in improving inflammatory responses and lipid handling, two crucial players in atherosclerosis development, here we aimed to investigate the effects of combined GIPR/GLP1R agonism in APOE\*3-Leiden.CETP mice, a well-established mouse model for human-like lipoprotein metabolism and atherosclerosis development. Methods Female APOE\*3-Leiden.CETP mice were fed a Western-type diet (containing 16% fat and 0.15% cholesterol) to induce dyslipidemia, and received subcutaneous injections with either vehicle, a GIPR agonist (GIPFA-085), a GLP1R agonist (GLP-140) or both agonists. In the aortic root area, atherosclerosis development was assessed. Results Combined GIPR/GLP1R agonism attenuated the development of severe atherosclerotic lesions, while single treatments only showed non-significant improvements. Mechanistically
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- Author
- Robin van Eenige; Zhixiong Ying; Naomi Tramper; Vera Wiebing; Zohor Siraj; Jan Freark de Boer; Joost M. Lambooij; Bruno Guigas; Hongchang Qu; Tamer Coskun; Mariëtte R. Boon; Patrick C.N. Rensen; Sander Kooijman
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)