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Can I read Magnetic Resonance Imaging to Study Lesions of Atherosclerosis in the Hyperlipidemic Rabbit Aorta on EtoBox?
Magnetic Resonance Imaging to Study Lesions of Atherosclerosis in the Hyperlipidemic Rabbit Aorta by Chun Yuan; Michael P. Skinner; Eiji Kaneko; Lee M. Mitsumori; Cecil E. Hayes; Elaine W. Raines; James A. Nelson; Russell Ross is a Medicine article available to read on EtoBox.
What is Magnetic Resonance Imaging to Study Lesions of Atherosclerosis in the Hyperlipidemic Rabbit Aorta about?
We have developed a high resolution magnetic resonance (MR) imaging technique to serially assess lesions of atherosclerosis in a rabbit model. A volume phased array coil was designed and used to image the abdominal aortas of six atherosclerotic rabbits and two age-, sex-, and weight-matched controls. Lesions of atherosclerosis were induced by a combination of repeat balloon injury and a hyperlipidemic diet. All animals were imaged on at least two occasions 9-16 months after initiation of atherosclerosis. In addition, animals were imaged immediately after sacrifice. Anatomic dissection and histology were performed to verify the MR findings. The volume phased array coil improves the image signal-to-noise ratio over existing extremity coils and resulted in higher resolution images of the abdominal aorta. Proton density-weighted images acquired with 2D/3D fast spin-echo are the most useful sequence to outline the vessel wall and to differentiate wall from lumen and background. Progressive wall thickening and lumen stenosis were observed in the serial images of the diseased rabbits. Wall thickness and lumen area derived noninvasively from the in vivo MR images correlate with postmortem
Who reads Magnetic Resonance Imaging to Study Lesions of Atherosclerosis in the Hyperlipidemic Rabbit Aorta?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chun Yuan; Michael P. Skinner; Eiji Kaneko; Lee M. Mitsumori; Cecil E. Hayes; Elaine W. Raines; James A. Nelson; Russell Ross
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)