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Rationale for CDK4/6 Inhibitors in Breast Cancer by tepat rshs is a document available to read on EtoBox.
What is Rationale for CDK4/6 Inhibitors in Breast Cancer about?
The document discusses CDK4/6 inhibitors, which target cyclin-dependent kinases CDK4 and CDK6. These enzymes are important for cell division, and CDK4/6 inhibitors interrupt signals that stimulate cancer cell proliferation. In breast cancer, overexpression of cyclin D1 leads to amplification and hyperactivity of CDK4/6, resulting in uncontrolled cell growth and tumor development. CDK4/6 inhibition restores cell cycle control by arresting cells in the G1 phase. The document also notes cross-talk between estr
- Author
- tepat rshs
- Language
- EN