Opening book details…
Can I read HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6‐mediated CD147 polyubiquitination on EtoBox?
HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6‐mediated CD147 polyubiquitination by Qi Song; Juyi Wen; Weiping Li; Janxin Xue; Yufei Zhang; Hongyan Liu; Jixia Han; Tao Ning; Zejun Lu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6‐mediated CD147 polyubiquitination about?
## Abstract HSP90 inhibition might be a promising strategy to overcome the radioresistance of some cancers. In the current study, we further explored the mechanisms of HSP90 in regulating the radiosensitivity of cervical cancer cells. Bioinformatic analysis was performed based on data from TCGA‐CESC. Cellular and molecular studies were conducted using CaSki and SiHa and the derived radioresistant (RR) subclones. Through a proteomics screen, we identified HSP90 chaperones (both HSP90α and HSP90β) as CD147‐binding partners supporting its stabilization. Targeting HSP90 sensitized CaSki‐RR and SiHa‐RR cancer cells to irradiation partially through CD147 destabilization. Mechanistically, HSP90 interacts with FBXO6 and reduces FBXO6‐mediated proteasomal degradation of CD147. Enforced __FBXO6__ overexpression also sensitized CaSki‐RR and SiHa‐RR cancer cells to irradiation. These effects were enhanced using 17‐AAG treatment but were weakened by __CD147__ overexpression. Survival analysis further confirmed the association between high __FBXO6__ expression and favorable progression‐free survival among patients with cervical cancer. In conclusion, this study showed that HSP90 promotes radiore
Who reads HSP90 promotes radioresistance of cervical cancer cells via reducing FBXO6‐mediated CD147 polyubiquitination?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Qi Song; Juyi Wen; Weiping Li; Janxin Xue; Yufei Zhang; Hongyan Liu; Jixia Han; Tao Ning; Zejun Lu
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)