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The influence of different InsP3 receptor isoforms on Ca2+ signaling in tracheal smooth muscle cells by Thomas Haberichter; Etienne Roux; Marko Marhl; Jean-Pierre Mazat is a Engineering article available to read on EtoBox.

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In airway myocytes, like in many cells, Ca(2+) signaling is controlled by inositol 1,4,5-trisphosphate (InsP(3)) via InsP(3) receptors (InsP(3)R) located in the sarco-endoplasmic reticulum. Three types of InsP(3)R exist, labeled Types 1, 2, and 3, which differ in their gating kinetics. We analyze a possible impact of the different gating kinetics of Type 1 and Type 3 InsP(3)R on the time course of cytosolic Ca(2+) concentration in tracheal smooth muscle cells upon agonist stimulation. Previous experimental data in rat tracheal myocytes showed that upon gradually increased stimulation with acetylcholine (ACh), a contractile agonist that acts via InsP(3) production, signal spikes, several spikes with declining maxima, and sustained oscillations appear. Our model reproduces the time courses of cytosolic Ca(2+) measured in tracheal myocytes. Moreover, by postulating slight variations in the model parameters which determine the total number of receptors expressed and the ratio between Type 1 and Type 3 InsP(3)R, it offers an explanation to the experimental observation of qualitatively different responses of cells within a presumably homogeneous tissue.

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Author

Thomas Haberichter; Etienne Roux; Marko Marhl; Jean-Pierre Mazat

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-5394)

Published

2002

Language

EN

Field

Engineering (Physical Sciences)