About this Medicine article

Evaluations of Lifestyle, Dietary, and Pharmacologic Treatments for Pediatric Nonalcoholic Fatty Liver Disease: A Systematic Review by Jake Peter Mann; George Yizhou Tang; Valerio Nobili; Matthew James Armstrong is a Medicine article available to read on EtoBox.

## Background & aims: There are no approved treatments for pediatric nonalcoholic fatty liver disease (nafld) and there is a lack of consensus on the best outcome measure for randomized controlled trials. we performed a systematic review of treatments tested for pediatric nafld, the degree of heterogeneity in trial design, and endpoints analyzed in these studies. ## Methods: We searched publication databases and clinical trial registries through january 7, 2018 for randomized controlled trials (published and underway) of children (<18 years) with nafld. we assessed improvements in histologic features, radiologic and biochemical markers of reduced fibrosis, metabolic syndrome parameters, and adverse events. the quality of the trials was assessed using a modified version of the cochrane risk of bias tool. ## Results: Our final analysis included 21 randomized controlled trials, comprising 1307 participants (mean age, 12.6 years; 63% male; mean duration of intervention, 8 months). most studies evaluated weight loss with lifestyle intervention (n=8), oral polyunsaturated fatty acid treatment (pufas, n=6), or oral antioxidant treatment (n=7). biomarkers of nafld decreased with weight los

Author

Jake Peter Mann; George Yizhou Tang; Valerio Nobili; Matthew James Armstrong

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1542-3565)

Published

2018

Language

EN

Field

Medicine (Health Sciences)