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Spiral analysis in Niemann-Pick disease type C by Annie W. Hsu; Panida A. Piboolnurak; Alicia G. Floyd; Qiping P. Yu; James E. Wraith; Marc C. Patterson; Seth L. Pullman is a Medicine article available to read on EtoBox.

What is Spiral analysis in Niemann-Pick disease type C about?

## Abstract Spiral analysis is a computerized method of analyzing upper limb motor physiology through the quantification of spiral drawing. The objective of this study was to determine whether spirals drawn by patients with Niemann‐Pick disease type C (NPC) could be distinguished from those of controls, and to physiologically characterize movement abnormalities in NPC. Spiral data consisting of position, pressure, and time were collected from 14 NPC patients and 14 age‐matched controls, and were analyzed by the Mann‐Whitney __U__ test. NPC spirals were characterized by: lower speed (2.67 vs. 9.56 cm/s, __P__ < 0.001) and acceleration (0.10 vs. 2.04 cm/s^2^, __P__ < 0.001), higher loop width variability (0.88 vs. 0.28, __P__ < 0.001), tremor (5/10 vs. 0/10 trials in the dominant hand, __P__ < 0.001), and poor overall spiral rating (2.53 vs. 0.70, __P__ < 0.005). NPC spirals also exhibited sustained drawing pressure profiles that were abnormally invariant with time. Other features, such as the tightness of loop widths, were normal. Our findings reveal that differing aspects of tremor, Parkinsonism, ataxia, and dystonia are quantifiable in NPC patients. © 2009 Movement Disorder Societ

Who reads Spiral analysis in Niemann-Pick disease type C?

Author

Annie W. Hsu; Panida A. Piboolnurak; Alicia G. Floyd; Qiping P. Yu; James E. Wraith; Marc C. Patterson; Seth L. Pullman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2009

Language

EN

Field

Medicine (Health Sciences)