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Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking by Michelle A. Tanchuck; Naomi Yoneyama; Matthew M. Ford; Andrea M. Fretwell; Deborah A. Finn is a Medicine article available to read on EtoBox.
What is Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking about?
Drinking to intoxication or binge drinking is a hallmark characteristic of alcohol abuse. Although hard to model in rodents, the scheduled high alcohol consumption (SHAC) procedure generates high, stable ethanol intake and blood ethanol concentrations in mice to levels consistent with definitions of binge drinking. The purpose of the present studies was to determine the effects of pharmacological manipulation of the opioidergic, glutamatergic, and g-aminobutyric acid (GABA)ergic systems on binge drinking with the SHAC procedure. Parallel manipulations were conducted in mice trained in operant self-administration of either sucrose or ethanol. For the SHAC procedure, genetically heterogeneous Withdrawal Seizure Control mice were given varying periods of fluid access, with a 30-min ethanol session every third day (total of seven). Mice were pretreated intraperitoneally with naltrexone (0, 0.6, or 1.25 mg/kg), baclofen (0, 2.5, or 5.0 mg/kg), or 2-methyl-6-(phenylethynyl)-pyridine (MPEP; 0, 3.0, or 10.0 mg/kg) before each ethanol session. For the operant self-administration procedure, separate groups of C57BL/6 mice were trained to complete a single response requirement (16 presses on
Who reads Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Michelle A. Tanchuck; Naomi Yoneyama; Matthew M. Ford; Andrea M. Fretwell; Deborah A. Finn
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)