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Levels of Peripheral Blood Polymorphonuclear Myeloid-derived Suppressor Cells and Selected Cytokines Are Potentially Prognostic of Disease Progression for Patients with Non-small Cell Lung Cancer by Lourdes Barrera; Edgar Montes-Servín; Juan-Manuel Hernandez-Martinez; Mario Orozco-Morales; Elizabeth Montes-Servín; David Michel-Tello; Renato Augusto Morales-Flores; Diana Flores-Estrada; Oscar Arrieta is a scholarly article available to read on EtoBox.

What is Levels of Peripheral Blood Polymorphonuclear Myeloid-derived Suppressor Cells and Selected Cytokines Are Potentially Prognostic of Disease Progression for Patients with Non-small Cell Lung Cancer about?

Polymorphonuclear-MDSC (PMN-MDSC) have emerged as an independent prognostic factor for survival in NSCLC. Similarly, cytokine profiles have been used to identify subgroups of NSCLC patients with different clinical outcomes. This prospective study investigated whether the percentage of circulating PMN-MDSC, in conjunction with the levels of plasma cytokines, was more informative of disease progression than the analysis of either factor alone. We analyzed the phenotypic and functional profile of peripheral blood T-cell subsets (CD3, CD3CD4 and CD3CD8), neutrophils (CD66b) and polymorphonuclear-MDSC (PMN-MDSC; CD66bCD11bCD15CD14-) as well as the concentration of 14 plasma cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12 p70, IL-17A, IL-27, IL-29, IL-31, and IL-33, TNF-α, IFN-γ) in 90 treatment-naïve NSCLC patients and 25 healthy donors (HD). In contrast to HD, NSCLC patients had a higher percentage of PMN-MDSC and neutrophils (P < 0.0001) but a lower percentage of CD3, CD3CD4 and CD3CD8 cells. PMN-MDSC% negatively correlated with the levels of IL1-β, IL-2, IL-27 and IL-29. Two groups of patients were identified according to the percentage of circulating PMN-MDSC. Patients with l

Author

Lourdes Barrera; Edgar Montes-Servín; Juan-Manuel Hernandez-Martinez; Mario Orozco-Morales; Elizabeth Montes-Servín; David Michel-Tello; Renato Augusto Morales-Flores; Diana Flores-Estrada; Oscar Arrieta

Published

2018

Language

EN