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Induction of the Proinflammatory Cytokine Interleukin‐18 by Axonal Injury by Til Menge; Sebastian Jander; Guido Stoll is a Neuroscience article available to read on EtoBox.

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## Abstract Interleukin‐18 (IL‐18) is an important cytokine in innate immunity and in the induction phase of autoimmunity. We report the expression of IL‐18 mRNA and protein after nerve crush during Wallerian degeneration (WD) of the rat nervous system. In normal optic nerves (ON) constitutive IL‐18 mRNA levels as revealed by semiquantitative reverse transcriptase polymerase chain reaction were higher than in sciatic nerves (SN). After nerve crush, steady‐state levels moderately increased in the distal nerve part of the SN but not the ON. By immunocytochemistry no SN or faint ON IL‐18 protein expression was detectable in normal nerves. In contrast, IL‐18 expression dramatically increased after SN and ON crush. On the cellular level, ED1^+^ macrophages infiltrating the crush site strongly expressed IL‐18 at days 2 and 4 after SN crush. By days 4 and 8, in addition, the entire distal nerve part was covered by IL‐18^+^ macrophages. At day 16, IL‐18 immunoreactivity had disappeared despite the presistence of large numbers of ED1^+^ macrophages. A similar infiltration of IL‐18^+^ macrophages was seen at the crush site in the ON. Moreover, microglia in the distal ON stump lacking macroph

Who reads Induction of the Proinflammatory Cytokine Interleukin‐18 by Axonal Injury?

Author

Til Menge; Sebastian Jander; Guido Stoll

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2001

Language

EN

Field

Neuroscience (Life Sciences)