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Serotonin–dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias by M CARTA; T CARLSSON; A MUNOZ; D KIRIK; A BJORKLUND is a book available to read on EtoBox.

What is Serotonin–dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias about?

Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.

Author

M CARTA; T CARLSSON; A MUNOZ; D KIRIK; A BJORKLUND

Publisher

Elsevier

Published

2008

Language

EN