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Can I read Myosin Light Chain Kinase Is a Potential Target for Hypopharyngeal Cancer Treatment on EtoBox?
Myosin Light Chain Kinase Is a Potential Target for Hypopharyngeal Cancer Treatment by Feng Cao; Le Zhu; Jing Zhang; Pawin Pongkorpsakol; Wei-Ting Kuo; Jerrold R. Turner; Qing Zhou; Yuan Wang; Feihu Chen; Yehai Liu; Li Zuo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Myosin Light Chain Kinase Is a Potential Target for Hypopharyngeal Cancer Treatment about?
Hypopharyngeal cancer is squamous cell carcinoma (SCC) with the worst prognosis among the head and neck cancers. Overall, the 5-year survival rate remains poor although diagnostic imaging, radiation, chemotherapy, and surgical techniques have been improved. The mortality of patients with hypopharyngeal cancer is partly due to an increased likelihood of developing a second primary malignancy and metastasis. In this study, we found that MLCK expression, compared to healthy tissue, was up-regulated in hypopharyngeal tumor tissue. Of particular interest, a low 5-year survival rate was positively correlated with MLCK expression. We hypothesized that MLCK might be a target for hypopharyngeal cancer prognosis and treatment. In order to explore the function of MLCK in the development of cancer, we knockdown MLCK in hypopharyngeal cancer FaDu cells. The results showed that MLCK knockdown reduced the migration and invasion of FaDu cells. 4-amino-2-trifluoromethylphenyl retinate (ATPR) is the derivative of all-trans retinoic acid (ATRA), which was able to reduce both MLCK expression and activity in FaDu cells. ATPR induced FaDu cells apoptosis in a dose-dependent manner and also inhibited cel
Who reads Myosin Light Chain Kinase Is a Potential Target for Hypopharyngeal Cancer Treatment?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Feng Cao; Le Zhu; Jing Zhang; Pawin Pongkorpsakol; Wei-Ting Kuo; Jerrold R. Turner; Qing Zhou; Yuan Wang; Feihu Chen; Yehai Liu; Li Zuo
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)