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Can I read Sub-millimeter variation in human locus coeruleus is associated with dimensional measures of psychopathology: An in vivo ultra-high field 7-Tesla MRI study on EtoBox?
Sub-millimeter variation in human locus coeruleus is associated with dimensional measures of psychopathology: An in vivo ultra-high field 7-Tesla MRI study by Morris, Laurel S.; Tan, Aaron; Smith, Derek A.; Grehl, Mora; Han-Huang, Kuang; Naidich, Thomas P.; Charney, Dennis S.; Balchandani, Priti; Murrough, James W.; Kundu, Prantik is a Medicine article available to read on EtoBox.
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## Highlights •We combined ultra-high field 7-Tesla and 0.4 × 0.4 × 0.5 mm quantitative MR imaging with a computational LC localization and segmentation algorithm. •LC was delineated in 29 human subjects including subjects with and without an anxiety or stress-related disorder. •Patients with an anxiety or stress-related disorder had larger LC compared to controls (Cohen's __d__ = 1.08, p = 0.024). •Larger LC was additionally associated with poorer attentional and inhibitory control and higher anxious arousal (FDR-corrected p's<0.025), trans-diagnostically across the full sample.
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- Author
- Morris, Laurel S.; Tan, Aaron; Smith, Derek A.; Grehl, Mora; Han-Huang, Kuang; Naidich, Thomas P.; Charney, Dennis S.; Balchandani, Priti; Murrough, James W.; Kundu, Prantik
- Publisher
- Elsevier ; Elsevier BV; Amsterdam: Elsevier (ISSN 2213-1582)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)