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Histology of Lichen Sclerosus Varies According to Site and Proximity to Carcinoma by James Scurry; Julie Whitehead; Martin Healey is a Medicine article available to read on EtoBox.

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To investigate why vulvar but not extragenital lichen sclerosus is associated with squamous cell carcinoma, we performed a histologic study of extragenital lichen sclerosus, vulvar lichen sclerosus without carcinoma, and vulvar lichen sclerosus with carcinoma adjacent to and distant from the carcinoma. We compared epidermal thickness, rete ridge length, mitotic activity, atypia, dermal collagen change, dermal inflammation, and presence of other dermatoses in 30 women in each group. Extragenital lichen sclerosus showed thinner epidermis (mean thickness of 0.13 mm versus 0.41 mm; P < 0.0005), shorter rete ridges (P ‫ס‬ 0.0001), more dermal edema (P ‫ס‬ 0.16), and absence of associated dermatoses of spongiotic dermatitis and lichen planus (P < 0.005) compared with vulvar lichen sclerosus. The epidermal thickening seen in vulvar lichen sclerosus was indistinguishable from lichen simplex chronicus. Vulvar lichen sclerosus without carcinoma was generally similar to that distant from carcinoma. Vulvar lichen sclerosus adjacent to carcinoma showed increased epidermal thickness (0.61 mm versus 0.26 mm; P < 0.005), more dermal fibrosis (P < 0.0005), more inflammation (P < 0.0005), and more s

Who reads Histology of Lichen Sclerosus Varies According to Site and Proximity to Carcinoma?

Author

James Scurry; Julie Whitehead; Martin Healey

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2001

Language

EN

Field

Medicine (Health Sciences)