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Spontaneous and Induced Appearance of Murine Leukemia Virus Antigen Containing Cells in Organ Cultures of Embryonic Mouse Thymus by Inger Riesenfeld; Gunnar V. Alm is a Medicine article available to read on EtoBox.
What is Spontaneous and Induced Appearance of Murine Leukemia Virus Antigen Containing Cells in Organ Cultures of Embryonic Mouse Thymus about?
## Abstract The potential of embryonic thymus organ cultures for studies on relations of endogenous MuLV, lymphoid cells and thymic microenvironment to lymphoma development were evaluated. Four main findings are reported. First, thymuses of 14‐day‐old CBA and AKR embryos could be maintained in organ cultures for at least 9 weeks with sustained production of lymphocytes. Lymphopoiesis in CBA and AKR thymuses were not grossly different. Secondly, an indirect immunofluorescence (IF) technique demonstrated spontaneous appearance of MuLV‐antigen‐containing cells in AKR, but not in CBA thymuses. Such spontaneous MuLV expression first occurred after 16 days of organ culture, thereafter infrequently and at random in individual thymus cultures. Thirdly, incubation of AKR and CBA thymuses in lymphoma extract containing AKR‐type MuLV at initiation of organ cultures induced MuLV‐antigen‐containing cells. These were first detected after 7‐14 days in culture, somewhat earlier and initially more frequently in AKR than in CBA thymuses. In the former, induction was accompanied by a clear reduction in the number of lymphocytes per thymus. Fourthly, iododeoxyuridine (IdUrd) treatment of AKR thymuses
Who reads Spontaneous and Induced Appearance of Murine Leukemia Virus Antigen Containing Cells in Organ Cultures of Embryonic Mouse Thymus?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Inger Riesenfeld; Gunnar V. Alm
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1977
- Language
- EN
- ISBN
- 9782910200220
- Field
- Medicine (Health Sciences)