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Metallomic Profiling and Natural Copper Isotopic Signatures of Childhood Autism in Serum and Red Blood Cells by Weibo Ling; Gang Zhao; Weichao Wang; Chao Wang; Luyao Zhang; Huazhou Zhang; Dawei Lu; Shasha Ruan; Aiqian Zhang; Qian Liu; Jie Jiang; Guibin Jiang is a Environmental Science article available to read on EtoBox.
What is Metallomic Profiling and Natural Copper Isotopic Signatures of Childhood Autism in Serum and Red Blood Cells about?
Excessive exposure to metals directly threatens human health, including neurodeve lopment. Autism spectrum disorder (ASD) is a neurodevelopmental disorder, leaving great harms to children themselves, their families, and even society. In view of this, it is critical to develop reliable biomarkers for ASD in early childhood. Here we used inductively coupled plasma mass spectrometry (ICP-MS) to identify the abnormalities in ASD-associated metal elements in children blood. Multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) was applied to detect isotopic differences in copper (Cu) for further assessment on account of its core role in the brain. We also developed a machine learning classification method for unknown samples based on a support vector machine (SVM) algorithm. The results indicated significant differences in the blood metallome (chromium (Cr), manganese (Mn), cobalt (Co), magnesium (Mg), and arsenic (As)) between cases and controls, and a significantly lower Zn/Cu ratio was observed in the ASD cases. Interestingly, we found a strong association of serum copper isotopic composition (δ 65Cu) with autistic serum. SVM was successfully applied to discriminat
Who reads Metallomic Profiling and Natural Copper Isotopic Signatures of Childhood Autism in Serum and Red Blood Cells?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Weibo Ling; Gang Zhao; Weichao Wang; Chao Wang; Luyao Zhang; Huazhou Zhang; Dawei Lu; Shasha Ruan; Aiqian Zhang; Qian Liu; Jie Jiang; Guibin Jiang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)