Can I read Haplotype Associations with Quantitative Traits in the Presence of Complex Multilocus and Heterogeneous Effects on EtoBox?

Haplotype Associations with Quantitative Traits in the Presence of Complex Multilocus and Heterogeneous Effects by Kyoko Shibata; Luda Diatchenko; Dmitri V. Zaykin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Haplotype Associations with Quantitative Traits in the Presence of Complex Multilocus and Heterogeneous Effects about?

## Abstract In genetic mapping of complex traits, scored haplotypes are likely to represent only a subset of all causal polymorphisms. At the extreme of this scenario, observed polymorphisms are not themselves functional, and only linked to causal ones via linkage disequilibrium (LD). We will demonstrate that due to such incomplete knowledge regarding the underlying genetic mechanism, the variance of a trait may become different between the scored haplotypes. Thus, unequal variances between haplotypes may be indicative of additional functional polymorphisms affecting the trait. Methods accounting for such haplotype‐specific variance may also provide an increased power to detect complex associations. We suggest ways to estimate and test these haplotypic variance contrasts, and incorporate them into the haplotypic tests for association. We further extend this approach to data with unknown gametic phase via likelihood‐based simultaneous estimation of haplotypic effects and their frequencies. We find our approach to provide additional power, especially under the following types of models: (a) where scored and unobserved variants are epistatically interacting with each other; and (b) un

Who reads Haplotype Associations with Quantitative Traits in the Presence of Complex Multilocus and Heterogeneous Effects?

Author

Kyoko Shibata; Luda Diatchenko; Dmitri V. Zaykin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0741-0395)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)