Can I read Regulatory effects of Th1‐type (IFN‐γ, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on parasite‐specific cellular responsiveness in Onchocerca volvulus ‐infected humans and exposed endemic controls on EtoBox?

Regulatory effects of Th1‐type (IFN‐γ, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on parasite‐specific cellular responsiveness in Onchocerca volvulus ‐infected humans and exposed endemic controls by Soboslay; Lüder; Riesch; Geiger; Banla; Batchassi; Stadler; Schulz‐Key is a Immunology and Microbiology article available to read on EtoBox.

What is Regulatory effects of Th1‐type (IFN‐γ, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on parasite‐specific cellular responsiveness in Onchocerca volvulus ‐infected humans and exposed endemic controls about?

The present study investigated __in vitro__ the regulatory effects of T helper 1 (Th1)‐type (interferon‐γ, IFN‐γ; interleukin‐12, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on __Onchocerca volvulus__‐specific cellular reactivity in onchocerciasis patients, and in exposed endemic control individuals presenting no clinical and parasitological signs of disease. In both patients and controls, addition of IL‐10 dose‐dependently depressed __O. volvulus__ antigen (OvAg)‐specific cellular proliferation, and peripheral blood mononuclear cells (PBMC) from patients who were more sensitive to the suppressive effect of IL‐10 than those from endemic controls. However, neutralization of IL‐10 by specific antibody did not reverse cellular hyporesponsiveness. In contrast to the inhibitory effects of IL‐10, exogenous IL‐12 and IL‐13 augmented PBMC proliferative responses to OvAg both in patients and controls (__P__<0·01) and neutralizing of IL‐12 or IL‐13 significantly decreased OvAg‐specific proliferation in both groups. Exogenous IFN‐γ did not activate OvAg‐specific proliferative responses in patients, but anti‐IFN‐γ antibodies abolished cellular reactivity to OvAg. Antibody to IL‐10 increased (

Who reads Regulatory effects of Th1‐type (IFN‐γ, IL‐12) and Th2‐type cytokines (IL‐10, IL‐13) on parasite‐specific cellular responsiveness in Onchocerca volvulus ‐infected humans and exposed endemic controls?

Author

Soboslay; Lüder; Riesch; Geiger; Banla; Batchassi; Stadler; Schulz‐Key

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)