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Chemopreventive Effects of Korean Red Ginseng Extract on Rat Hepatocarcinogenesis by Kim, Hyemee; Hong, Mi-Kyung; Choi, Haymie; Moon, Hyun-Seuk; Lee, Hae-Jeung is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The objective of this study was to determine a chemopreventive activity of Korean red ginseng extract (KRG) in diethylnitrosamine (DEN) induced hepatocarcinogenesis in rats. After acclimatization for a week, Sprague-Dawley rats were randomized into five groups (n = 15) and fed either KRG (0.5, 1 or 2%) or control diets for 10 weeks. After two weeks of starting of experimental diets, the rats were initiated hepatocarcinogenesis by injection of DEN and were then subjected to two-thirds partial hepatectomy at five-week for developing the medium-term bioassay system. Both 0.5 and 1% KRG diets suppressed the area (55 and 60%; p= 0.0251 and 0.0144) and number (39 and 59%; p= 0.0433 and 0.0012) of glutathione S-transferase placental form (GST-P) positive foci when compared to the DEN-control group. The production of thiobarbituric acid reactive substances (TBARS) was significantly reduced in 0.5 and 1% KRG-treated rats. The supplementation of 1% KRG diet significantly elevated the levels of total glutathione (tGSH) and glutathione-related enzymes including cytosolic glutathione S-transferase (GST) and glutathione peroxidase (GPx) activities. It was also observed in cDNA microarray that th

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Author

Kim, Hyemee; Hong, Mi-Kyung; Choi, Haymie; Moon, Hyun-Seuk; Lee, Hae-Jeung

Publisher

Ivyspring International Publisher; Wyoming N.S.W.: Ivyspring International Publisher, 2010- (ISSN 1837-9664)

Published

2015

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)