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Clinical Pharmacokinetics of Intravenous and Oral 9-Amino-1,2,3,4-tetrahydroacridine, Tacrine by P. Hartvig; H. Askmark; S. M. Aquilonius; L. Wiklund; B. Lindstrm is a Medicine article available to read on EtoBox.
What is Clinical Pharmacokinetics of Intravenous and Oral 9-Amino-1,2,3,4-tetrahydroacridine, Tacrine about?
The pharmacokinetics of 9-amino-1,2,3,4-tetrahydroacridine; tacrine, THA, was studied after intravenous administration and following the first and last oral doses of a seven week clinical trial involving 8 patients with amyotrophic lateral sclerosis, ALS. Two surgical patients given intravenous THA for reversal of postoperative sedation were also included. Plasma concentration of THA and in some cases the metabolite, 1-hydroxy-THA, were assayed using a selective and sensitive method with high performance liquid chromatography. After an intravenous dose of 30 mg THA, the plasma concentrations were fitted to a two-compartment model. Plasma clearance showed a threefold interindividual variation with a mean of 2.42 l.h-1. Volume of distribution, V alpha varied 100-680 l with a mean of 349 l. The plasma half-lives of distribution and elimination were 1.8 and 98.2 min, respectively. Oral bioavailability showed large interindividual differences and ranged 6-36% in the four subjects studied. After seven weeks treatment with oral THA, plasma concentrations immediately prior to medication were below 10 ng/ml in three patients and above 100 ng/ml in two patients. At the same occasion the plas
Who reads Clinical Pharmacokinetics of Intravenous and Oral 9-Amino-1,2,3,4-tetrahydroacridine, Tacrine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- P. Hartvig; H. Askmark; S. M. Aquilonius; L. Wiklund; B. Lindstrm
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0031-6970)
- Published
- 1990
- Language
- EN
- Field
- Medicine (Health Sciences)