Can I read Guidelines for Establishing Locus Specific Databases on EtoBox?

Guidelines for Establishing Locus Specific Databases by Mauno Vihinen; Johan T. den Dunnen; Raymond Dalgleish; Richard G. H. Cotton is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Guidelines for Establishing Locus Specific Databases about?

Information about genetic variation has been collected for some 20 years into registries, known as locus specific databases (LSDBs), which nowadays often contain information in addition to the actual genetic variation. Several issues have to be taken into account when considering establishing and maintaining LSDBs and these have been discussed previously in a number of articles describing guidelines and recommendations. This information is widely scattered and, for a newcomer, it would be difficult to obtain the latest information and guidance. Here, a sequence of steps essential for establishing an LSDB is discussed together with guidelines for each step. Curators need to collect information from various sources, code it in systematic way, and distribute to the research and clinical communities. In doing this, ethical issues have to be taken into account. To facilitate integration of information to, for example, analyze genotype-phenotype correlations, systematic data representation using established nomenclatures, data models, and ontologies is essential. LSDB curation and maintenance comprises a number of tasks that can be managed by following logical steps. These resources are

Who reads Guidelines for Establishing Locus Specific Databases?

Author

Mauno Vihinen; Johan T. den Dunnen; Raymond Dalgleish; Richard G. H. Cotton

Publisher

Hindawi Limited

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)