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Impact of Sterile Leukocyturia on Outcome of Critically Ill Patients with Severe Acute Kidney Injury by Sílvia Coelho; Margarida Monteiro; Joana Santos; Francisco Correia; Patrícia Rodrigues; Matilde Rito; Paulo Freitas is a Medicine article available to read on EtoBox.

What is Impact of Sterile Leukocyturia on Outcome of Critically Ill Patients with Severe Acute Kidney Injury about?

## Introduction: The role of immunological mechanisms on renal regeneration and functional recovery after an episode of Acute Kidney Injury (AKI) is still understudied. We aim to evaluate the impact of sterile leukocyturia on outcomes of critically-ill AKI patients. Methods: A retrospective analysis of critically-ill patients with stage ≥2 AKI by KDIGO was performed. Patients with urinary tract infection, previous renal replacement therapy, chronic kidney disease stage >3 and kidney, urinary tract or prostatic cancer were excluded. Sterile leukocyturia was defined as a positive leukocyte esterase value. Results: 108 patients with stage ≥2 AKI were included, 39.8% of which had sterile leukocyturia. AKI patients with sterile leukocyturia were older, had more cardiovascular disease and a lower baseline renal function (p < 0.05). They had a higher serum creatinine and leukocytosis at admission, were more frequently septic (p < 0.05) and had more persistent AKI by both KDIGO criteria at multivariable analysis (OR 6.130, 95% CI 2.007-18.747). Conclusion: Sterile leukocyturia was associated with different patient baseline and AKI characteristics and more persistent AKI by both KDIGO crite

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Author

Sílvia Coelho; Margarida Monteiro; Joana Santos; Francisco Correia; Patrícia Rodrigues; Matilde Rito; Paulo Freitas

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)