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Probiotics and Synbiotics for the Prevention of Postoperative Infections Following Abdominal Surgery: a Systematic Review and Meta-analysis of Randomized Controlled Trials by L. Lytvyn; K. Quach; L. Banfield; B.C. Johnston; D. Mertz is a Medicine article available to read on EtoBox.

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## Background: Postoperative infections, particularly surgical site infections (ssis), cause significant morbidity and mortality. probiotics or synbiotics are a potential prevention strategy. ## Aim: To evaluate the efficacy of probiotics/synbiotics for reducing postoperative infection risk following abdominal surgery. ## Methods: We searched amed, central, cinahl, embase, medline, and grey literature for randomized controlled trials of elective abdominal surgery patients administered probiotics or synbiotics compared to placebo or standard care. primary outcome was ssis. secondary outcomes were adverse events, respiratory tract infections (rtis), urinary tract infections (utis), combined infections, length of hospital stay, and mortality. using random-effects meta-analyses, we estimated the relative risk (rr) or mean difference (md) and 95% confidence interval (ci). tests were performed for heterogeneity, subgroup and sensitivity analyses were conducted, and the overall evidence quality was graded. ## Findings: We identified 20 trials (n = 1374 participants) reporting postoperative infections. probiotics/synbiotics reduced ssis (rr: 0.63; 95% ci: 0.41-0.98; n = 15 studies), utis (

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Author

L. Lytvyn; K. Quach; L. Banfield; B.C. Johnston; D. Mertz

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0195-6701)

Published

2015

Language

EN

Field

Medicine (Health Sciences)