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Usp7‐Dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors by de la Vega, Eduardo; González, Natalia; Cabezas, Felipe; Montecino, Fabián; Blanco, Natasha; Olguín, Hugo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Usp7‐Dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors about?
Satellite cells (SCs) are myogenic progenitors responsible for skeletal muscle regeneration and maintenance. Upon activation, SCs enter a phase of robust proliferation followed by terminal differentiation. Underlying this myogenic progression, the sequential expression of muscle regulatory transcription factors (MRFs) and the downregulation of transcription factor paired box gene 7 (Pax7) are key steps regulating SC fate. In addition to transcriptional regulation, post‐translational control of Pax7 and the MRFs provides another layer of spatiotemporal control to the myogenic process. In this context, previous work showed that Pax7 is ubiquitinated by the E3 ligase neural precursor cell‐expressed developmentally downregulated protein 4 and interacts with several proteins related to the ubiquitin–proteasome system, including the deubiquitinase ubiquitin‐specific protease 7 (USP7). Although USP7 functions in diverse cellular contexts, its role(s) during myogenesis remains poorly explored. Here, we show that USP7 is transiently expressed in adult muscle progenitors, correlating with the onset of myogenin expression, while it is downregulated in newly formed myotubes/myofibers. Acute in
Who reads Usp7‐Dependent control of myogenin stability is required for terminal differentiation in skeletal muscle progenitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- de la Vega, Eduardo; González, Natalia; Cabezas, Felipe; Montecino, Fabián; Blanco, Natasha; Olguín, Hugo
- Publisher
- John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)