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The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family by Kimiko Tanaka; Koji Okabayashi; Makoto Asashima; Norbert Perrimon; Tatsuhiko Kadowaki is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The __Drosophila__ segment polarity gene product Porcupine (Porc) was first identified as being necessary for processing Wingless (Wg), a __Drosophila__ Wnt (Wnt) family member. Mouse and __Xenopus__ homologs of __porc__ (__Mporc__ and __Xporc__) were identified and found to encode endoplasmic reticulum (ER) proteins with multiple transmembrane domains. In contrast with __porc,__ four different types of __Mporc__ and __Xporc__ mRNA (A–D) are generated from a single gene by alternative splicing. __Mporc__ mRNA is differentially expressed during embryogenesis and in various adult tissues, demonstrating that the alternative splicing is regulated to synthesize the specific types of Mporc. In transfected mammalian cells, all Mporc types affect the processing of mouse Wnt 1, 3A, 4, 6, and 7B but not 5A. Furthermore, all Mporc types are co‐immunoprecipitated with various Wnt proteins. These results suggest that Mporc may function as a chaperone‐like molecule for Wnt. Interestingly, all Mporc types can substitute for Porc, as they are able to rescue the phenotypes of __Drosophila porc__ embryos. Consistent with this observation, Mporc, like Porc, modifies the processing of Wg expressed in

Who reads The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family?

Author

Kimiko Tanaka; Koji Okabayashi; Makoto Asashima; Norbert Perrimon; Tatsuhiko Kadowaki

Publisher

John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)