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Clinical and Laboratory Observations in a Lymphoma-prone Family by Jeffrey W. Clark; Margaret A. Tucker; Mark H. Greene is a Medicine article available to read on EtoBox.

What is Clinical and Laboratory Observations in a Lymphoma-prone Family about?

Three sisters developed non-Hodgkin's lymphoma (NHL). Thirteen maternal relatives had adenocarcinomas of various types, predominantly breast and large bowel. Detailed laboratory assessment of this family revealed a variety of immunologic abnormalities. Two lymphoma patients had elevated anti-early antigens (EA) Epstein-Barr virus (EBV) titers. One of the two also had a markedly elevated anti-viral capsid antigen (VCA) EBV titer. The two lymphoma patients were human leukocyte antigen (HLA)-identical, but two unaffected siblings shared the same HLA haplotypes. One of the lymphoma patients and four unaffected family members were anergic; and three unaffected family members had a decreased percentage of T-cells. These data suggest that a subtle disturbance in cellular immune functions may play a causal role in some familial aggregations of malignant lymphoma.

Who reads Clinical and Laboratory Observations in a Lymphoma-prone Family?

Author

Jeffrey W. Clark; Margaret A. Tucker; Mark H. Greene

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1987

Language

EN

Field

Medicine (Health Sciences)