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Prenatal Arsenic Exposure, Arsenic Metabolism and Neurocognitive Development of 2-Year-old Children in Low-arsenic Areas by Huan Chen; Hongling Zhang; Xin Wang; Yi Wu; Yiqiong Zhang; Silan Chen; Wenxin Zhang; Xiaojie Sun; Tongzhang Zheng; Wei Xia; Shunqing Xu; Yuanyuan Li is a Environmental Science article available to read on EtoBox.
What is Prenatal Arsenic Exposure, Arsenic Metabolism and Neurocognitive Development of 2-Year-old Children in Low-arsenic Areas about?
Background There is limited evidence on the effects of arsenic species and metabolic capacity on child neurodevelopment, particularly at low levels. Further, little is known about the critical window of exposure. Objective To estimate the associations of arsenic exposure and arsenic metabolism in different pregnancy periods with neurodevelopment of two-year-old children. Methods Concentrations of arsenobetaine (AsB), arsenite, arsenate, monomethyl arsenic acid (MMA), and dimethyl arsenic acid (DMA) in urine samples collected in three trimesters from 1006 mothers were measured using HPLC − ICPMS. Inorganic arsenic (iAs) was calculated as the sum of arsenite and arsenate. Total arsenic (tAs) was calculated as the sum of iAs, MMA and DMA. Child neurodevelopment was assessed with the Bayley Scales of Infant Development. Results The geometric mean (GM) of SG-adjusted tAs in the first, second, third trimester was 16.37, 12.94, 13.04 μg/L, respectively. The mental development index (MDI) score was inversely associated with iAs and tAs. Compared to the 1st quartile, the MDI score decreased 0.43 (95%CI: −4.22, 3.36) for the 2nd, 6.50 (95%CI: −11.73, −1.27) for the 3rd, 5.42 (95%CI: −10.74,
Who reads Prenatal Arsenic Exposure, Arsenic Metabolism and Neurocognitive Development of 2-Year-old Children in Low-arsenic Areas?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Huan Chen; Hongling Zhang; Xin Wang; Yi Wu; Yiqiong Zhang; Silan Chen; Wenxin Zhang; Xiaojie Sun; Tongzhang Zheng; Wei Xia; Shunqing Xu; Yuanyuan Li
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)