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Can I read The Snake Venom Metalloproteases Berythractivase and Jararhagin Activate Endothelial Cells on EtoBox?
The Snake Venom Metalloproteases Berythractivase and Jararhagin Activate Endothelial Cells by Mirta Schattner; Márcio Fritzen; Janaína de Souza Ventura; Jeanne Claíne de Albuquerque Modesto; Roberto Gabriel Pozner; Ana Maria Moura-da-Silva; Ana Marisa Chudzinski-Tavassi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The Snake Venom Metalloproteases Berythractivase and Jararhagin Activate Endothelial Cells about?
PIII snake venom metalloproteases (SVMPs) are metalloproteases structurally related to ADAMs (a disintegrin and metalloprotease human family of proteins). Berythractivase and jararhagin are PIII SVMPs with 69% homology that have different hemostatic properties. In order to clarify these differences and further characterize the biological effects of these proteins, we have analyzed the effect of both proteases on human umbilical-vein endothelial cell functions. We found that both proteins enhanced nitric oxide generation, prostacyclin production and interleukin-8 release. Berythractivase but not jararhagin increased the expression of decay accelerating factor. Jararhagin decreased cell viability in a concentration-dependent manner and induced cellular apoptosis, while berythractivase did not modulate cell survival. Our results show for the first time that, besides the known anti-aggregating or procoagulant effects of PIII SVMPs, these proteins trigger endothelial cell effector responses. Although structurally related, berythractivase and jararhagin induce a dissimilar generation and release of endothelial molecules that may account for their different hemorrhagic activity.
Who reads The Snake Venom Metalloproteases Berythractivase and Jararhagin Activate Endothelial Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mirta Schattner; Márcio Fritzen; Janaína de Souza Ventura; Jeanne Claíne de Albuquerque Modesto; Roberto Gabriel Pozner; Ana Maria Moura-da-Silva; Ana Marisa Chudzinski-Tavassi
- Publisher
- Walter de Gruyter GmbH
- Published
- 2005
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)