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The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling by Yousuke Ebina; Leland Ellis; Kurt Jarnagin; Marc Edery; Laszlo Graf; Eric Clauser; Jing-hsiung Ou; Frank Masiarz; Y.W. Kan; I.D. Goldfine; Richard A. Roth; William J. Rutter is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling about?

A cloned -5 kb cDNA (human placenta) contains the coding sequences for the insulin receptor. The nucleotide sequence predicts a 1382 amino acid precursor. The (I subunit comprises the N-terminal portion of the precursor and contains a striking cysteine-rich tress-linking" domain. The /I-subunit (the C-terminal portion of the precursor) contains a transmembrane domain and, in the intracellular region, the elements of a tyrosine phosphokinase:an ATP-binding site and a possible tyrosine autophosphorylation site or sites. The overall structure Is reminiscent of the EGF recep tor; the cross-linking domain of the (I subunit and several regions of the fi subunit exhibit sequence homology with the EGF receptor. The phosphoklnase domain also exhibits homology with some oncogenic proteins that have tyrosine phosphokinase activity, in particular, a striking homology with wros. Southern blotting experiments suggest that the coding region spans more than 45 kb. The insulin receptor gene is located on chromosome 19.

Who reads The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling?

Author

Yousuke Ebina; Leland Ellis; Kurt Jarnagin; Marc Edery; Laszlo Graf; Eric Clauser; Jing-hsiung Ou; Frank Masiarz; Y.W. Kan; I.D. Goldfine; Richard A. Roth; William J. Rutter

Published

1985

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)