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Injectable Multifunctional Composite Hydrogel as a Combination Therapy for Preventing Postsurgical Adhesion by Ke Lv; Peng Lou; Shuyun Liu; Yizhuo Wang; Jinlin Yang; Pingya Zhou; Xiyue Zhou; Yanrong Lu; Hongren Wang; Jingqiu Cheng; Jingping Liu is a Engineering article available to read on EtoBox.
What is Injectable Multifunctional Composite Hydrogel as a Combination Therapy for Preventing Postsurgical Adhesion about?
## Abstract Postsurgical adhesion (PA) is a common and serious postoperative complication that affects millions of patients worldwide. However, current commercial barrier materials are insufficient to inhibit diverse pathological factors during PA formation, and thus, highly bioactive materials are needed. Here, this work designs an injectable multifunctional composite hydrogel that can serve as a combination therapy for preventing PA. In brief, this work reveals that multiple pathological events, such as chronic inflammatory and fibrotic processes, contribute to adhesion formation in vivo, and such processes can not be attenuated by barrier material (e.g., hydrogel) alone treatments. To solve this limitation, this work designs a composite hydrogel made of the cationic self‐assembling peptide KLD2R and TGF‐β receptor inhibitor (TGF‐βRi)‐loaded mesenchymal stem cell‐derived nanovesicles (MSC‐NVs). The resulting composite hydrogel displays multiple functions, including physical separation of the injured tissue areas, antibacterial effects, and local delivery and sustained release of anti‐inflammatory MSC‐NVs and antifibrotic TGF‐βRi. As a result, this composite hydrogel effectively i
Who reads Injectable Multifunctional Composite Hydrogel as a Combination Therapy for Preventing Postsurgical Adhesion?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Ke Lv; Peng Lou; Shuyun Liu; Yizhuo Wang; Jinlin Yang; Pingya Zhou; Xiyue Zhou; Yanrong Lu; Hongren Wang; Jingqiu Cheng; Jingping Liu
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)