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Bacteriophages and Their Host Range in Multidrug-Resistant Bacterial Disease Treatment by Ka Mun Chung; Xiew Leng Liau; Swee Seong Tang is a Medicine article available to read on EtoBox.

What is Bacteriophages and Their Host Range in Multidrug-Resistant Bacterial Disease Treatment about?

The rapid emergence of multidrug-resistant (MDR) bacteria in recent times has prompted the search for new and more potent antibiotics. Bacteriophages (commonly known as phages) are viruses that target and infect their bacterial hosts. As such, they are also a potential alternative to antibiotics. These phages can be broadly categorized into monovalent (with a narrow host range spectrum and specific to a single bacterial genus) and polyvalent (with a broad host range and specific to more than two genera). However, there is still much ambiguity in the use of these terms, with researchers often describing their phages differently. There is considerable research on the use of both narrow- and broad-host range phages in the treatment of infections and diseases caused by MDR bacteria, including tuberculosis, cystic fibrosis, and carbapenem-resistant __Enterobacterales__ (CRE) infectious diseases. From this, it is clear that the host range of these phages plays a vital role in determining the effectiveness of any phage therapy, and this factor is usually analyzed based on the advantages and limitations of different host ranges. There have also been efforts to expand phage host ranges via

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Author

Ka Mun Chung; Xiew Leng Liau; Swee Seong Tang

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Life Sciences)