Can I read Platelet‐derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis on EtoBox?

Platelet‐derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis by Gina C. Schatteman; S. Tim Motley; Eric L. Effmann; Daniel F. Bowen‐Pope is a Medicine article available to read on EtoBox.

What is Platelet‐derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis about?

## Abstract __Path (Ph)__ mice, whose platelet‐derived growth factor receptor alpha subunit (αPDGFR) gene has been deleted, have been used to elucidate requirements for αPDGFR for normal murine development. In this report we evaluate the role of αPDGFR in cardiovascular development by using in situ hybridization to follow the changing pattern of αPDGFR expression in cardiovascular tissues after embryonic day 13, and comparing this pattern with the pattern of cardiovascular defects observed in homozygous __Ph__ mutants. Both mesodermally derived and neural crest‐derived components of the cardiovascular system are severely dysmorphic in __Ph/Ph__ embryos and those structures most severely affected are those that normally express αPDGFR mRNA at the highest levels and for the longest duration. __Ph/Ph__ vessels appear to be lined with a normal endothelium, but contain a reduced number of smooth muscle cells and are fragile during processing for histology. The myocardium is thin, the heart is small and dysmorphic, the valves are malformed, and the interventricular and interatrial septa of the heart are defective. In the outflow tract, the spectrum of defects includes both persistent tru

Who reads Platelet‐derived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis?

Author

Gina C. Schatteman; S. Tim Motley; Eric L. Effmann; Daniel F. Bowen‐Pope

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0040-3709)

Published

1995

Language

EN

Field

Medicine (Health Sciences)