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Senescent Skeletal Cells Cross-talk with Synovial Cells Plays a Key Role in the Pathogenesis of Osteoarthritis by Chong-Jie Wu; Ri-Xu Liu; Song-Wei Huan; Wang Tang; Yu-Kai Zeng; Jun-Cheng Zhang; Jie Yang; Zhen-Yan Li; Ying Zhou; Zhen-Gang Zha; Huan-Tian Zhang; Ning Liu is a Medicine article available to read on EtoBox.
What is Senescent Skeletal Cells Cross-talk with Synovial Cells Plays a Key Role in the Pathogenesis of Osteoarthritis about?
## Abstract Osteoarthritis (OA) has been recognized as an age-related degenerative disease commonly seen in the elderly that affects the whole “organ” including cartilage, subchondral bone, synovium, and muscles. An increasing number of studies have suggested that the accumulation of senescent cells triggering by various stresses in the local joint contributes to the pathogenesis of age-related diseases including OA. In this review, we mainly focus on the role of the senescent skeletal cells (chondrocytes, osteoblasts, osteoclasts, osteocyte, and muscle cells) in initiating the development and progression of OA alone or through cross-talk with the macrophages/synovial cells. Accordingly, we summarize the current OA-targeted therapies based on the abovementioned theory, e.g., by eliminating senescent skeletal cells and/or inhibiting the senescence-associated secretory phenotype (SASP) that drives senescence. Furthermore, the existing animal models for the study of OA from the perspective of senescence are highlighted to fill the gap between basic research and clinical applications. Overall, in this review, we systematically assess the current understanding of cellular senescence in
Who reads Senescent Skeletal Cells Cross-talk with Synovial Cells Plays a Key Role in the Pathogenesis of Osteoarthritis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Chong-Jie Wu; Ri-Xu Liu; Song-Wei Huan; Wang Tang; Yu-Kai Zeng; Jun-Cheng Zhang; Jie Yang; Zhen-Yan Li; Ying Zhou; Zhen-Gang Zha; Huan-Tian Zhang; Ning Liu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)