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Fluorinated CSNK2 Inhibitor for Antiviral Use by zeeyanmotahir is a document available to read on EtoBox.
The article discusses the development of a potent and selective inhibitor of the host kinase casein kinase 2 (CSNK2) as a potential antiviral target against β-coronaviruses. Through strategic fluorination of a previously characterized compound, a new lead compound was discovered that exhibits improved metabolic stability, excellent potency, and selectivity for CSNK2. Despite its favorable pharmacokinetic properties, the compound showed only modest and transient inhibition of CSNK2 in vivo, which limited its
- Author
- zeeyanmotahir
- Language
- EN