About this Medicine article
Transmission of hepatitis B virus through allotransplantation by Gish, Robert G. ;Ascher, Nancy L. is a Medicine article available to read on EtoBox.
Liver allograftsfrom HBcAb(+), IgM(-), HBsAg(-) donors can transmit HBV to uninfected recipients. We currently no longer accept these livers for transplantation while continuing to accept the kidneys. The purpose of this study is to determine the risk of donor-transmitted HBV infections from HBcAb(+), HBIgM(-), HBsAg(-) organ donors and determine if the risk of donor-transmitted HBV infections and their severity is dependent on the organ being transplanted. This study consists of a retrospective review of the posttransplant course of recipients of HBcAb(+), HBIgM(-), HBsAg(-) donors accepted at UCSF from 6/85 to 12/93. Transmitted HBV infection was defined as one in which the recipient changed from HB-sAg(-) prior to transplantation to HBsAg(+) posttransplant, with no other source. There were 25 of 1190 donors who were HBcAb(+), HBIgM(-), HBsAg(-); 1 /42 kidney, 3/6 liver, and 0/7 heart HBsAg(-) transplant recipients of organs from these donors became HBsAg( +) after transplantation. This difference in infection rate (liver vs. kidney and heart) is statistically significant. The clinical course of liver recipients was also more severe. All of the patients who became infected were H
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- Author
- Gish, Robert G. ;Ascher, Nancy L.
- Publisher
- Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1074-3022)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)