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Synthesis and Preliminary Studies of Biological Activity of Amino Derivatives of 4-Azatricyclo- [5.2.1.0^2,6^]Dec-8-ene-3,5-dione with Silicon in the Structure by Mariola Napiórkowska; Marcin Cieślak; Julia Kaźmierczak-Barańska; Karolina Królewska; Aleksandra Czapla; Bożena Kuran is a Chemistry article available to read on EtoBox.

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## Abstract A series of 38 new derivatives of cyclic imides containing silicon in the structure was synthesized and characterized by ^1^H NMR, ESI-MS, and elemental analysis. Selected compounds (1l,m, 1g, 1o,p, 2l,m, and 2o,p) were tested for their cytotoxic properties in human chronic myelogenous leukemia (K562), human cervical cancer (HeLa), and normal endothelial cells (HUVEC). Seven compounds showed significant cytotoxicity. In addition, two compounds (1l and 2l) were tested toward affinity for 5-HT~1A~, 5-HT~6~, and 5-HT~7~ serotonin receptors, and all aryl/heteroarylopiperazino derivatives were tested for antimicrobial activity. The compounds tested toward affinity for selected serotonin receptors showed high and moderate affinity for 5-HT~1A~ and 5-HT~7~, while the antimicrobial activity of tested compounds was not significant.

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Author

Mariola Napiórkowska; Marcin Cieślak; Julia Kaźmierczak-Barańska; Karolina Królewska; Aleksandra Czapla; Bożena Kuran

Publisher

Walter de Gruyter GmbH

Published

2015

Language

EN

Field

Chemistry (Physical Sciences)