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Karyotypic evolution in B-cell chronic lymphocytic leukaemia by David Oscier; Margaret Fitchett; Tony Herbert; Richard Lambert is a Medicine article available to read on EtoBox.

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Sequential cytogenetic studies were performed on a minimum of two and a maximum of nine occasions (mean 3.6) on the peripheral blood leucocytes of 112 patients with B-CLL. On initial cytogenetic analysis, 58 had a normal karyotype and 64 had a clonal abnormality. Karyotypic evolution occurred in 18 patients (16%). There was no significant difference in the incidence of disease progression between patients with a stable karyotype and those who underwent karyotypic evolution. In only one patient was there a clear association between disease progression, a change in cell morphology and karyotypic evolution.

Who reads Karyotypic evolution in B-cell chronic lymphocytic leukaemia?

Author

David Oscier; Margaret Fitchett; Tony Herbert; Richard Lambert

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

1990

Language

EN

Field

Medicine (Life Sciences)