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The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis by Lijuan Zhang; Aziz M. Uluǧ; Robert D. Zimmerman; Michael T. Lin; Michael Rubin; M. Flint Beal is a Medicine article available to read on EtoBox.

What is The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis about?

## Abstract ## Purpose To explore the overall diagnostic ability of magnetic resonance (MR) fluid‐attenuated inversion recovery (FLAIR) imaging for clinically verified amyotrophic lateral sclerosis (ALS). ## Materials and Methods Abnormal signal intensity in FLAIR images of 18 patients with ALS and 18 age‐matched normal controls were scored and compared. Six patients had serial MR imaging scans within 97 days. Mann Whitney U statistics and ANOVA were used for statistical analysis. ## Results Hyperintensity in the subcortical white matter (SWM) and the dark line along the posterior rim of the precentral gyri were found more frequently in patients with ALS. The scores for these two signs were significantly different from those of normal controls. Hyperintensity in the corticospinal tract (CST) was found in both ALS and normal controls, but the difference was not statistically significant. ANOVA on the serial FLAIR studies revealed no significant difference in the scores among the series. The hyperintensity in SWM had a sensitivity of 56% and specificity of 94%, while the dark line in the motor cortex had a 74% sensitivity and 67% specificity. ## Conclusion Hyperintensity in SWM and t

Who reads The diagnostic utility of FLAIR imaging in clinically verified amyotrophic lateral sclerosis?

Author

Lijuan Zhang; Aziz M. Uluǧ; Robert D. Zimmerman; Michael T. Lin; Michael Rubin; M. Flint Beal

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-1807)

Published

2003

Language

EN

Field

Medicine (Health Sciences)