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Muscarinic Receptors, from Synaptic Plasticity to its Role in Network Activity by D. Fernández de Sevilla; A. Núñez; W. Buño is a scholarly article available to read on EtoBox.

What is Muscarinic Receptors, from Synaptic Plasticity to its Role in Network Activity about?

Acetylcholine acting via metabotropic receptors plays a key role in learning and memory by regulating synaptic plasticity and circuit activity. However, a recent overall view of the effects of muscarinic acetylcholine receptors (mAChRs) on excitatory and inhibitory long-term synaptic plasticity and on circuit activity is lacking. This review focusses on specific aspects of the regulation of synaptic plasticity and circuit activity by mAChRs in the hippocampus and cortex. Acetylcholine increases the excitability of pyramidal neurons, facilitating the generation of dendritic Ca-spikes, NMDA-spikes and action potential bursts which provide the main source of Ca influx necessary to induce synaptic plasticity. The activation of mAChRs induced Ca release from intracellular IP-sensitive stores is a major player in the induction of a NMDA independent long-term potentiation (LTP) caused by an increased expression of AMPA receptors in hippocampal pyramidal neuron dendritic spines. In the neocortex, activation of mAChRs also induces a long-term enhancement of excitatory postsynaptic currents. In addition to effects on excitatory synapses, a single brief activation of mAChRs together with shor

Author

D. Fernández de Sevilla; A. Núñez; W. Buño

Publisher

Elsevier BV

Published

2020

Language

EN