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Is Obesity Associated with an Increased Risk for Airway Hyperresponsiveness and Development of Asthma? by Sat Sharma; Adarsh Tailor; Richard Warrington; Mary Cheang is a Medicine article available to read on EtoBox.

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## Abstract We investigated the association between airway hyperresponsiveness (AHR) and obesity in adults referred for confirmation of asthma diagnosis. Data were analyzed for obesity class I (body mass index [BMI] 30-34.9 kg/m^2^), class II (BMI ≥ 35-39.9 kg/m^2^), and class III (BMI ≥ 40 kg/m^2^). Of 861 subjects, 401 demonstrated AHR; the mean dose of methacholine was 4.16 ± 2.55 mg/mL. A significant association between obesity and AHR was evident for all subjects: the odds ratio was 1.37 (95% CI 1.02-1.82; __p__ = .0317). One unit of increased BMI (1 kg/m^2^) was associated with a 3.1% increase in AHR risk (95% CI 1.01-1.05, __p__ < .005). The odds ratio increased from 1.86 (95% CI 1.27-1.76; __p__ = .0012) for class I to 2.61 (95% CI 1.48-4.60; __p__ = .0006) for class III. Obesity was found to be associated with AHR and appears to be a risk factor for asthma.

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Author

Sat Sharma; Adarsh Tailor; Richard Warrington; Mary Cheang

Publisher

BC Decker; BioMed Central; Decker, Inc.; Springer (Biomed Central Ltd.); Hamilton Ont.: 2004-2009; [London]: Oct. 2009-; Springer Science and Business Media LLC (ISSN 1710-1492)

Published

2008

Language

EN

Field

Medicine (Health Sciences)