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Helicobacter Pylori-specific Tumour-infiltrating T Cells Provide Contact Dependent Help For The Growth Of Malignant B Cells In Low-grade Gastric Lymphoma Of Mucosa-associated Lymphoid Tissue by HUSSELL, TRACEY; ISAACSON, PETER G.; CRABTREE, JEAN E.; SPENCER, JO is a Medicine article available to read on EtoBox.

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Previous studies have shown that tumour cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue (MALT) type proliferate in vitvo in response to heat-killed whole cell preparations of Helicobactev pylovi, but only in the presence of tumour-infiltrating T cells. This response is strain-specific in that the tumours studied responded optimally to different strains of H. pylovi. It was unclear from these studies, however, whether the ability to recognize the specific stimulating strains of H. pylovi was a property of the tumour cells or the tumour-infiltrating T cells. This study shows that whereas the tumour cells do not respond to H. pylovi, both freshly isolated tumour-infiltrating T cells and a T cell line derived from these cells proliferate in response to stimulating strains of H. pylovi. T cells from the spleen of one of the patients do not share this property. These results suggest that B-cell proliferation in cases of low-grade gastric lymphoma of MALT type in vitvo in response to ff. pyIori is due to recognition of H. pylovi by tumour-infiltrating T cells, which in turn provide help for tumour cell proliferation. The observations provide an explanati

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Author

HUSSELL, TRACEY; ISAACSON, PETER G.; CRABTREE, JEAN E.; SPENCER, JO

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1996

Language

EN

Field

Medicine (Health Sciences)