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This research article explores how the fate of pyruvate influences cell growth by modulating cellular redox potential, particularly in liver-like cells and Drosophila fat body cells. The study finds that increased mitochondrial pyruvate import leads to reduced protein synthesis and cell growth due to a shift in metabolism toward gluconeogenesis, driven by an elevated NADH/NAD+ ratio. These findings highlight the critical role of pyruvate metabolism in balancing energy production and biosynthesis in speciali

Author

julsama305

Language

EN