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Can I read Development of a panel of autoantibody against NSG1 with CEA, CYFRA21-1, and SCC-Ag for the diagnosis of esophageal squamous cell carcinoma on EtoBox?
Development of a panel of autoantibody against NSG1 with CEA, CYFRA21-1, and SCC-Ag for the diagnosis of esophageal squamous cell carcinoma by Qingzhu Zheng; Liangming Zhang; Mingshu Tu; Xiaoqing Yin; Liqing Cai; Songgao Zhang; Lili Yu; Xiaojie Pan; Yi Huang is a Medicine article available to read on EtoBox.
What is Development of a panel of autoantibody against NSG1 with CEA, CYFRA21-1, and SCC-Ag for the diagnosis of esophageal squamous cell carcinoma about?
## Objective: Development of a panel of serum autoantibody against neuron specific gene family member 1 (nsg1) with traditional tumor biomarkers of esophageal squamous cell carcinoma (escc) to further improve the diagnostic efficiency for escc patients. ## Methods: Immunohistochemistry (ihc) staining was used to detect the expression of nsg1 protein in 40 pairs of escc tissues and matched paracancerous tissues. serum anti-nsg1 levels of 203 patients with early escc, 103 patients with advanced escc, 135 patients with esophageal benign lesion (ebl), and 155 healthy controls (hcs) were detected by elisa. the diagnostic performances of all possible combinations of serum anti-nsg1with cea, cyfra21-1 and scc-ag were assessed to develop an optimal panel for escc diagnosis. ## Results: Nsg1 protein expression in escc tissues was significantly higher than that in matched paracancerous tissues (p < 0.001). serum anti-nsg1 expression in escc group was significantly higher than that in ebl group and hc group (p < 0.001). the auc of serum anti-nsg1 for escc was 0.706, with 49.7% sensitivity at 93.5% specificity, superior to that of cea, cyfra21-1 and scc-ag. of all possible combinations, serum
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- Author
- Qingzhu Zheng; Liangming Zhang; Mingshu Tu; Xiaoqing Yin; Liqing Cai; Songgao Zhang; Lili Yu; Xiaojie Pan; Yi Huang
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)